Segmentation by staining and AI algorithms
X, Y, Z transcript locations at subcellular sensitivity
Novel discoveries are just around the corner with CosMx high-plex RNA panels (1,000–6,000 targets). CosMx detects transcripts across a wide dynamic range, including low expressors. Confirm those transcript locations with CosMx protein panels.
Take advantage of the Olink platform for matching tissue data with plasma/serum.
With 1,000-plex and 6,000-plex RNA panels, CosMx is designed for making big discoveries.
Get to know your cells and their environment. With subcellular sensitivity and high-plex transcripts, CosMx delivers a map of all cells within the selected region.
Cell-to-cell communications are critical for understanding biological processes. Whether the goal is to delve into development, evaluate treatment impact in a PDX model, or monitor disease progression, the CosMx platform delivers.
Expression profiling at subcellular resolution. Designed for cell typing and cell-cell interaction analysis in a wide range of human tissues.
Customize with up to 50 targets.
Expression profiling at subcellular resolution focused on immune infiltration of the tumor microenvironment.
Customize with up to 10 targets.
Designed for high-plex analysis of up to 68 proteins from a single FFPE slide with spatial context at single-cell resolution. CosMx protein assays are already optimized for multiplexed performance and expand your reach beyond IHC/IF.
Expression profiling at subcellular resolution for mouse neuronal tissues. Designed for cell typing and cell-cell interaction analysis.
Customize with up to 50 targets.
High-plex analysis of up to 68 proteins from a single FFPE slide at subcellular resolution. Optimized for multiplexing to identify key post-translationally modified proteins as well as neuronal cell typing.
Includes 1,000 targets covering cell types, cell states, and cell signaling across a variety of tissue types. Ten negative control targets are also included for analysis of results. The panel is configured as a 950 target core plus controls, and a 50 target add-on that could be replaced with a custom add-on.
| CosMx Kit Description | Kit Components |
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RNA
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CosMx Human Universal Cell Segmentation Kit (RNA)
6k-plex, 1000-plex, and 100 plex assays
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CosMx Human Neuroscience Cell Segmentation Kit (RNA)
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CosMx Mouse Neuroscience Cell Segmentation Kit (RNA)
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CosMx Mouse Universal Cell Segmentation Kit (RNA)
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Protein
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CosMx Human Universal Cell Segmentation Kit (Protein)
Channels 1 and 2
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CosMx Human Supplemental Segmentation Kit (Protein)
Channels 3 and 4
(Optional)
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CosMx Mouse Neuroscience Cell Segmentation Kit (protein)
Channels 1 and 2
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CosMx Mouse Neuroscience Segmentation Kit (protein)
Channels 3 and 4
(Required)
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CosMx Mouse NeuN A La Carte Marker (protein)
Channel 5
(Required)
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| Assay | Item Description |
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RNA
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Human Universal RNA
Channel 5
(Optional)
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Mouse Universal RNA
Channel 5
(Optional)
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Protein
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Human IO Protein
Channel 5
(Optional)
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Get the instructions you need for fresh frozen and FFPE tissue preparation.
